Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Vegan - The product is made without ingredients produced by or derived from animals

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Coenzyme Q10 
Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a water-insoluble, wax-like substance, that is part of the respiratory chain. It is synthesized in the cells, and is involved in electron transport and energy production in mitochondria. In the cellular system, it functions to generate energy from oxygen, in the form of ATP, for bodily processes. CoQ10 also exhibits activity as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes protects against peroxidation of lipid membranes. Combining CoQ10 with vitamin E generates a synergistic antioxidant effect on lipoprotein and spares the vitamin E. Coenzyme Q10 can be found in spinach, broccoli, nuts, meats and fish. In the body, it is found in the highest concentration in the cells of the heart, liver, kidney and pancreas. Supplementation of CoQ10 might be beneficial mostly to adults, because the levels of it in the body tend to peak around the age of twenty, and then decline with age. The effects of supplementation with CoQ10 have shown to be especially helpful in maintaining heart health. 

Vitamin E 
Since vitamin E is one of the most powerful fat-soluble antioxidants in the body, it helps protect cell membranes from the effects of free radicals. Vitamin E works with Coenzyme Q10 for antioxidant protection. High intake of vitamin E have also been found support a healthy heart. Vegetable oils, margarine, nuts, seeds, avocados, wheat germ, and safflower oil are all good food sources of vitamin E. Vitamin E is linked to a healthy heart, enhancement of immune system function and support of healing. 

Lipase 
Lipase is a fat-digesting enzyme that supports the body’s ability to break down dietary fats into an absorbable form. It is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water-insoluble, lipid substrates. Lipase, such as human pancreatic lipase, support the conversion of triglyceride substrates found in oils from food to monoglycerides and free fatty acids. Lipases are ubiquitous in living organisms, and most are built on an alpha/beta hydrolase fold and employ a chymotrypsin-like hydrolysis mechanism involving a serine nucleophile, an acid residue and a histidine. Some lipases also work within the interior spaces of living cells to promote the normal degradation of lipids.

1. What is Coenzyme Q10? 
   Coenzyme Q10 is actually a two-part compound that is composed of (1) a long, fat-soluble isoprenoid tail that anchors the molecule in the inner membrane of the mitochondria and (2) a quinone that is capable of accepting and transferring electrons through a portion of the respiratory chain. A coenzyme is a non-protein substance that helps enzymes carry out their metabolic function and is not consumed in the reaction. The "Q" stands for quinone and the "10" stands for the number of isoprenoid units in the tail portion of the molecule. Mammals generally have 10 isoprenoid units in the tail portion, but other non-mammalian species may have fewer units. Coenzyme Q10 is a critical biochemical link in the production of energy in the cell. Coenzyme Q10 is found in the cell membranes of all cells in our body, particularly in the inner mitochondrial membranes, and it is especially concentrated in highly active organs such as the heart, lungs, kidneys, spleen, and adrenal glands. The mitochondria produce large amounts of adenosine triphosphate (ATP), which helps cells perform work. Since the manufacture of adenosine triphosphate (ATP) in the mitochondria is known to generate many oxygen radicals, coenzyme Q10 serves an antioxidant function in that location by neutralizing radicals. Coenzyme Q10 also promotes the Kreb's cycle (Citric Acid Cycle), which converts both carbohydrates and fat into usable energy for the cell. Besides these functions within all cells, coenzyme Q10 also works with vitamin E outside of the cell when both compounds are dissolved in circulating low-density lipoprotein (LDL) particles carrying cholesterol. These two fat-soluble antioxidants promote arterial health. 
   
   
2. What is the source of Coenzyme Q10? 
   While our livers produce small amounts of coenzyme Q10 and this small amount is distributed to the rest of the body, we get most of this compound from foods such as organ meats, muscle meats, fish, peanuts, spinach, soy, and nuts. In the past it was difficult and very expensive to isolate sufficient amounts of coenzyme Q10 from these food sources for the purpose of dietary supplementation. However, a Japanese company succeeded in synthesizing coenzyme Q10 in 1977, thus making an important nutrient available to the world. 
   
   
3. What is a safe and effective dose of supplemental Coenzyme Q10? 
   A variety of clinical studies has demonstrated that daily servings of as low as 30 mg and as high as 300 mg of coenzyme Q10 are safe and can promote a healthy life. The circulating levels of coenzyme Q10 take about 60-90 days to reach steady state, depending on the serving size taken. Granular coenzyme Q10, as used in Isotonix^®, is about equal to the oil-based form in terms of uptake from the small intestine and distribution throughout the body. 
   
   
4. If my body makes CoQ10, why should I take a supplement? 
   When you are young, your body can produce adequate levels of CoQ10. However, as you get older, your cells do not produce enough of the energy they need to function well. Supplementation of CoQ10 has been shown to raise blood levels of this co-enzyme when the body’s ability to synthesize it begins to decrease. 
   
   
5. What is the recommended serving size of Coenzyme Q10? 
   Coenzyme Q10 has been used in maintenance servings of 30-60 mg, but can go up to 100 mg or more. 
   
   
6. Is there a certain time I should take CoQ10? 
   Coenzyme Q10 should be taken with a meal containing some fat. Taking it in combination with soy or vegetable oil substantially enhances it absorption. 
   
   
7. Is it safe to take CoQ10? 
   Yes, it is safe to take CoQ10; it does not produce any toxic side effects when ingested by humans. It is listed in the 42^nd edition of the Physicians’ Desk Reference as replacement therapy for a nutrient, and no adverse reactions are listed. 
   
   
8. Is it okay to take a CoQ10 supplement while pregnant or nursing? 
   No. The safety of coenzyme Q10 has not been established in pregnancy and lactation. 
   
   
9. Is it safe to take CoQ10 while using blood pressure medicine? 
   If you are currently using blood pressure medication, you should consult your healthcare practitioner before using this product. Discontinue use if allergic reaction occurs.

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